Effects Of Deep Brain Stimulation on Parkinson's Disease as Viewed From The Basal Ganglia Network

Abstract

This article focuses on the resolution strategy of deep brain stimulation to improve Parkinson's disease symptoms by correcting pathological concussions of the basal ganglia network. Years of clinical practice have shown that Subthalamic nucleus (STN) and Internal globus pallidus (GPI) are two effective sites for DBS intervention in Parkinson's disease. Through the observation of animal experiments and drug intervention, the characteristics of pathological oscillations of basal ganglia network and spontaneous oscillations among various nuclei were sorted out. Based on the functional system hypothesis of cortical-basal ganglia-thalamo-cortical loops, the pathological oscillation pattern of the -band is analyzed, and how electrical impulse stimulation changes the generation pattern of action potentials at the cellular level, thereby effectively changing pathological oscillations at the network level; This paper analyzes the improvement of symptoms such as tremor, rigidity, and frozen gait with DBS, and looks forward to a composite treatment strategy.