Effects of Deanxit on depression and clinical outcomes in elderly patients with acute coronary syndrome

Abstract

Objective To investigate deanxit clinical efficacy of depression in elderly patients with acute coronary syndrome(ACS). Methods 88 elderly patients with ACS and depression were randomly divided into Deanxit (2 tablets daily; Deanxit, n=43) or placebo (control, n=45) treatment in addition to standard therapy. SDA score, SDS score, MACE and cardiac autonomic nerve function were performed at 12 weeks follow-up. Results In deanxit group, SDA score and SDS score were significantly reduced (34.28±6.35 vs 52.68±5.74, 41.19±4.63 vs 54.68±4.32, P<0.05), MACE were also decreased (4.6% vs 28.9%, P<0.05). SDNN were significantly higher than control (109.03±23.08 vs 98.29±27.44, P<0.05), but LF was reduced (152.89±92.75 vs 249.21±64.17, P<0.05). Conclusion Deanxit can improve the depression and clinical symptoms in elderly patients with ACS and depression. By improving the cardiac autonomic nerve function, deanxit possible reduce the onset of severe arrhythmia and improve the short-term prognosis. Key words: Deanxit; Acute coronary syndrome; Depression; Heart rate variability