Abstract
Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae). In this study, we analyzed the effects of DSU, SAB and a S. miltiorrhiza extract (SME) on cell proliferation. Additionally, the effects of DSU and SAB on collagen synthesis in Detroit 551 human normal fibroblast cells and on melanin production in B16 melanoma cells were verified. The results demonstrated that SME can enhance the proliferation of Detroit 551 cells and that this boost may be caused by DSU and SAB. This research showed that SME, DSU and SAB all have the ability to increase the production of collagen in Detroit 551 cells. The results also confirmed that DSU and SAB can attenuate the α-MSH-stimulated melanin production of B16 cells by inhibiting tyrosinase activity. Therefore, SME, DSU and SAB each have the potential to be utilized as active ingredients in wound healing or cosmetic treatments. In the future, DSU and SAB could also be used as functional components for treating hyperpigmentation.
Highlights
Salvia miltiorrhiza Bunge (Lamiaceae), generally known as danshen, is an important and widely used medicinal plant in Traditional Chinese Medicine (TCM)
We first evaluated the effects of DSU, salvianolic acid B (SAB) and S. miltiorrhiza extract (SME) on the growth of Detroit 551 human normal fibroblast cells
We suggest that some other functional components in SME strongly increase melanin production in melanoma cells; this effect must be stronger than the inhibition of melanin production provided by DSU and SAB
Summary
Salvia miltiorrhiza Bunge (Lamiaceae), generally known as danshen, is an important and widely used medicinal plant in Traditional Chinese Medicine (TCM). The chemical components of an extract of S. miltiorrhiza are classified into two main groups: water-soluble (hydrophilic) phenolic compounds and lipid-soluble (nonpolar, lipophilic) diterpenoidal compounds. These active components of S. miltiorrhiza, including tanshinones, tanshinlactone, salvianolic acids and danshensu, have potent antioxidant, antimicrobial, anticancer and cardioprotective functions [5,6,7]. We analyzed the effects of danshensu and salvianolic acid B on collagen synthesis in Detroit 551 normal fibroblast cells and on melanin production in B16 melanoma cells. The effects of danshensu, salvianolic acid B and a S. miltiorrhiza extract on cell proliferation were tested
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
