Abstract
Objective To investigate the role of D1-like dopamine receptor on insulin receptor-mediated proliferation of vascular smooth muscle cells. Methods A10 cells were used in this study and the mechanisms of D1-like receptor on insulin receptor were determined by immunoblotting. The proliferation of VSMC cells was determined by [3H]-TdR incorporation. Results Insulin increased proliferation of A10 cells in a concentration-dependent manner. D1-like receptor, by itself, had no effect on cell proliferation, but blocked the insulin-mediated proliferation of A10 cells.
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