Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.

Juanli Ji,Huarui Cai,Wei Sun,Erhu Zhao,Zhongze Wang,Zekun Li,Hongjuan Cui

doi:10.3390/ijms222212125

Juanli Ji, Huarui Cai + Show 5 more

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https://doi.org/10.3390/ijms222212125

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Abstract

The Chinese medicine monomer cynaroside (Cy) is a flavonoid glycoside compound that widely exists in plants and has a variety of pharmacological effects, such as its important role in the respiratory system, cardiovascular system and central nervous system. Studies have reported that Cy has varying degrees of anticancer activity in non-small cell lung cancer, cervical cancer, liver cancer, esophageal cancer and other cancers. However, there are no relevant reports about its role in gastric cancer. The MET/AKT/mTOR signaling pathway plays important roles in regulating various biological processes, including cell proliferation, apoptosis, autophagy, invasion and tumorigenesis. In this study, we confirmed that Cy can inhibit the cell growth, migration and invasion and tumorigenesis in gastric cancer. Our finding shows that Cy can block the MET/AKT/mTOR axis by decreasing the phosphorylation level of AKT, mTOR and P70S6K. Therefore, the MET/AKT/mTOR axis may be an important target for Cy. In summary, Cy has anti-cancer properties and is expected to be a potential drug for the treatment of gastric cancer.

Highlights

IntroductionPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
Cynaroside (Cy), called luteoloside or luteolin 7-glucoside, is a flavonoid glycoside compound widely found in plants, and mainly found in honeysuckle, snow chrysanthemum, brocade lantern, celery and other plants
The results showed that after treatment with Cy, the quantity of gastric cancer cells changed significantly, and with increasing Cy concentration, the number of cells decreased in a concentration-dependent manner (Figure 1A,B)

Summary

Introduction

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Gastric cancer is a malignant tumor of the digestive tract originating from the epithelium of the gastric mucosa. In 2020, there will be more than one million new cases and an estimated 769,000 deaths. The incidence of gastric cancer ranks fifth, and the mortality rate ranks fourth [1,2].

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