Abstract
Cyclohexylamine (CHA) was tested for possible dominant lethal mutations in male rats. Female rats were mated with CHA-treated males and were then examined for the number of corpora lutea, total number of implantations and the number of implantations regarded as early deaths. The results showed significant pre-implantation loss in females mated during wk 1 and 2 after intraperitoneal treatment of the males with 100 or 300 mg CHA/kg. The number of early deaths was not significant. An average of 35% of the ova flushed 48 hr after insemination from the oviducts of females mated with CHA-treated males showed no cleavage and did not exhibit two pronuclei. This indicated that fertilization had not occurred. It is concluded that the pre-implantation loss in females mated with CHA-treated males results from some mechanism other than that of dominant lethal mutation.
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