Abstract
AbstractInclusion complexes of indomethacin (IND) and β-cyclodextrins (β-CD) were prepared by the freeze drying methods. Solid dispersion of IND and Dimyristoylphosphatidylcholine (DMPC) was prepared as coprecipitate (CPPT) by the solvent method. These formulations were characterized by X-ray diffractometry and dissolution rate determinations. Dissolution of IND from β-CD inclusion complex was found to be 133 times faster than the corresponding pure IND, whereas it was about 4 times faster from a DMPC CPPT sample. Various derivatives of β-CDs showed variable rates of dissolution of IND. β-CD and most of the other derivatives showed almost instantaneous dissolution of IND at a molar ratio of 1:1 (IND:β-CD) except dimethyl-β-cyclodextrin (DMB) derivative, which showed a fairly constant release of IND over 90 minutes. DMB may, therefore, have the potential for use in the formulation of a constant-release preparation. X-ray diffraction spectra showed that indomethacin remained as amorphous state in CPPT or in...
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