Effects of Cyanoacrylate on the Gastric Mucosa of Dogs –Endoscopic and Histopathological Studies for Sclerotherapy of Gastric Varices–

Abstract

Abstract: The effect of cyanoacrylate tissue adhesive (C. A.) on the gastric mucosa of dogs was investigated endoscopically and histopathologically. When C. A. was applied to the surface of the gastric mucosa, the endoscopic findings the next day showed local redness at the applied site (Fig. 1‐a) and histopathology revealed degenerative changes in the gastric mucosa (Fig. 1‐b). When C. A. was endoscopically injected into the gastric mucosa, the endoscopic findings revealed a submucosal tumor‐like lesion (Fig. 2‐a). One day after treatment, the endoscopic findings showed a hemorrhagic erosion on the surface of the lesion (Fig. 2‐b). An histopathological examination of the resected stomach revealed C. A. in the submucosal layer (Fig. 3‐a, 3‐b) and the lymph duct around the muscularis mucosa with severe acute inflammation (Fig. 4‐a, 4‐b). One week after treatment, a deep ulcer (Ul‐IV) was observed (Fig. 5, 6) and a histopathological examination of the resected specimen revealed C. A. at the site of the ulcer and inflammatory cell infiltration by fibroblasts and giant cells (Fig. 7‐a, 7‐b). One month after treatment, the ulcer had healed and was replaced by a scar (Fig. 8). Histopathological examination of the resected stomach revealed C. A. in both the muscularis mucosa and the submucosa and also inflammatory cell infiltration by giant cells in addition to the fibrosis (Fig. 9). When using endoscopic sclerotherapy with C. A., it should be kept in mind that there is the possibility of such a lesion occurring as demonstrated by our study.