Abstract
Aging is characterized by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues throughout the lifespan. Senescence is occurring following enormous intracellular or extracellular stress stimuli. Cellular senescence serves as an antiproliferative process that causes permanent cell cycle arrest and restricts the lifespan. Senescent cells are characterized by terminal cell cycle arrest, enlarged lysosome, and DNA double-strand breaks as well as lipofuscin granularity, senescence-associated heterochromatin foci, and activation of DNA damage response. Curcumin, a hydrophobic polyphenol, is a bioactive chemical constituent of the rhizomes of Curcuma longa Linn (turmeric), which has been extensively used for the alleviation of various human disorders. In addition to its pleiotropic effects, curcumin has been suggested to have antiaging features. In this review, we summarized the therapeutic potential of curcumin in the prevention and delaying of the aging process.
Highlights
Aging is identified by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues with advancing age [1]
Previous researches identified several molecules and signaling pathways involved in the aging process: among them, growth hormone (GH)/insulin-like growth factor 1(IGF1)/forkhead box O (FOXO) pathway, target of rapamycin (TOR)/ribosomal S6 kinase (S6K), sirtuins (Sirts), p38 mitogen-activated protein kinase (MAPK), and AMP-activated protein kinase (AMPK) [6,7,8]
Cellular senescence was firstly described by Hayflick and Moorhead [27] as an antiproliferative process leading to permanent cell cycle arrest lifespan reduction [25]
Summary
Aging is identified by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues with advancing age [1]. Senolytics are drugs that target senescent cells through promoting the apoptosis of senescence [9,10,11] In this field of research, there is a growing interest towards the natural compound curcumin (CUR; diferuloylmethane), which is known as an active therapeutic compound against various human disorders owing to its numerous pharmacological actions [12,13,14,15,16,17]. Research groups worldwide are attempting to clarify biological pathways, pharmaceutical properties, and potential clinical application of CUR [18] In this narrative review, we will summarize the therapeutic potential of CUR, especially focusing on prevention and delaying of the aging process
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
