Abstract
Simple and reproducible formulation strategies are needed to improve the bio-availability of curcumin. In this study, curcumin was successfully complexed with two boron-based compounds: 2-aminoethyl diphenyl borate (DPBA) and bortezomib (BTZ; Velcade®). In reverse-phase high-performance liquid chromatography, DPBA/curcumin complexes (DPBA/cur) showed delayed elution times compared to those of free curcumin. The UV–visible absorbance peak of DPBA/cur and BTZ and curcumin complexes (BTZ/cur) appeared redshifted. DPBA complexation has a negligible effect on the antioxidant and antiproliferation properties of curcumin for two types of cancer cells: MCF-7 and A549. Thus, curcumin complexation with boron-based compounds could be a method to enhance in vivo stability without loss of bioactivity (i.e., antioxidant and antiproliferation effects).
Highlights
Curcumin, chemically known as diferuloyl methane, is an active polyphenol mainly derived from turmeric (Curcuma longa) [1]
The antiproliferation activity of curcumin and diphenyl borate (DPBA)/cur was examined for two types of cells, MCF-7 and A549, to assess the biological activity of curcumin-/boron-based compound complexes
DPBA was used as a stabilizer for keto-enol tautomer of curcumin, which increased in vivo stability of curcumin [14]
Summary
Chemically known as diferuloyl methane, is an active polyphenol mainly derived from turmeric (Curcuma longa) [1]. To determine the effect of boronic complexation with curcumin on radical scavenging activity, free curcumin and DPBA/cur were analyzed using a 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay at different curcumin concentrations. The antiproliferation activity of curcumin and DPBA/cur was examined for two types of cells, MCF-7 and A549, to assess the biological activity of curcumin-/boron-based compound complexes.
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