Effects of Cu deficiency and of dietary Cu intake on the distribution of 64Cu in the rat

Abstract

Rats were given Cu-deficient and control diets for up to 28 weeks before receiving an intraperitoneal injection of 64Cu. Cu deficiency resulted in reduced growth, anaemia and reduced concentrations of both direct reacting and caeruloplasmin fractions of plasma. The concentration of Cu in some soft tissues was decreased. Maximal plasma concentrations of 64Cu did not occur until about 2 h. after injection and were generally greater in Cu-deficient than in control rats. In soft tissues, also, 64Cu concentrations were usually greater in Cu-deficient rats and the significance of this finding as an indication of increased net uptake due to Cu deficiency is discussed. No effect of dietary Cu on the uptake of 64Cu by individual tissues was observed during the first 24 h. after injection.