Abstract
1. 1. The effects of 200 mg. of cortisone daily for three weeks upon gastric secretion and parietal cell mass were measured in 6 dogs with Heidenhain pouches, 3 with Pavlov pouches, and 3 with Heidenhain pouches plus antrectomy. 2. 2. The 24-hour secretory volume, free HCl, and total acid were all significantly increased during cortisone treatment in dogs with both innervated and denervated pouches. 3. 3. The antrectomized dogs showed a small but statistically insignificant increment in acid secretion on cortisone treatment. 4. 4. The maximum secretory response to histamine showed a twofold increase during cortisone administration in the 4 dogs so studied. 5. 5. The mean parietal cell population was significantly decreased—13% in dogs with Heidenhain pouches and 17% in dogs with Pavlov pouches. Since an increased secretion of histamine is usually associated with an increase in parietal cell mass, the rise in gastric acid secretion was attributed to an increased parietal cell sensitivity to normal stimuli in cortisone-treated dogs.
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