Abstract
Purpose: Proliferation is an important function of the retinal pigment epithelial (RPE) cells. The effect of a corticosteroid on the proliferation of cultured porcine RPE cells was investigated. Methods: After administration of various concentrations (10–1,000 nM) of betamethasone sodium phosphate (betamethasone), we counted RPE cell numbers at 1, 3, 6, 9, and 14 days. Results: Betamethasone administration resulted in a dose-dependent decrease in RPE cell proliferation. The proliferation of the cultured RPE cells was significantly inhibited by betamethasone, at a dose of 300 nM in 9 days. Ten nanomolar betamethasone neither inhibited nor promoted the RPE cell proliferation in culture. Conclusions: These results suggest that corticosteroids inhibit proliferation of cultured porcine RPE cells. (J Jpn Ophthalmol Soc 103:436–441, 1999)
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