Effects of Coronary Collateral Circulation on Tp-e interval, Tp-e/QT and Tp-e/QTc Ratios in Coronary Artery Disease Patients

Abstract

Background: Coronary collateral circulation (CCC) identifies the severity of ischemic myocardial injury. Tp-e/QT ratio and Tp-e/QTc ratio are known as indicators of ventricular arrhythmogenesis. Aim of our study was to assess the effect of CCC on ventricular arrhythmogenesis in coronary artery disease patients using these new markers. Methods: Fifty five patients who have at least one occluded major coronary artery were included in our study. Study population were divided into two groups according to the Rentrop collateral scoring system with poor (Rentrop score 0-1, n1⁄426) and good (score 2-3, n1⁄429) CCC. We collected fasting blood samples before the coronary angiography. Results: QT dispersion (QTd) (27.8 4.5, 25.6 3.9 P1⁄40.011), corrected QTd (33.3 7.4, 30.8 5.8, P1⁄40.017), cTp-e interval (84.5 7.5, 72.0 5.7, P<0.001), Tp-e/QT (0.26 0.03, 0.18 0.03, P<0.001) and Tp-e/QTc ratios (0.21 0.02, 0.15 0.03, P<0.001) were significantly higher in good CCC patients compared to poor group. We found significant positive correlations between the collateral score with Tp-e/QT and Tp-e/QTc ratios (r1⁄40.444, P<0.001, r1⁄40.418, P<0.001, respectively). Conclusion:We found higher cTp-e interval, Tp-e/QT and Tp-e/QTc ratios in patients with good CCC than in poor CCC. We consider that cTp-e interval, Tp-e/QT and Tp-e/QTc ratios are likely to be useful indices of ventricular arrhythmias in coronary artery disease patients, especially who have good CCC. PP-155