Abstract
Maltobionic acid is known to have an inhibitory effect on the differentiation of osteoclasts, and it has also been reported in an intervention trial that ingestion of corn syrup solids containing maltobionic acid maintained and increased the bone density of postmenopausal women. However, there is no information on whether maltobionic acid improves bone metabolism in humans. Therefore, we evaluated the influence of corn syrup solids containing maltobionic acid (maltobionic acid calcium salt) on bone resorption markers in healthy Japanese women. Forty‐one individuals were selected from 68 participants and assigned to two groups: 21 individuals in the test food antecedent group and 20 individuals in the placebo food antecedent group; individuals in the first group ingested 4 g of corn syrup solids containing maltobionic acid, and subjects in the second group ingested 4 g of placebo (hydrous crystalline maltose and calcium carbonate) for 4 weeks. Bone resorption marker levels (DPD and u‐NTx) were evaluated by urinalysis. Forty subjects completed the study, and no adverse events related to the test food were observed. Fourteen subjects were excluded prior to the efficacy analysis because of conflict with the control criteria; the remaining 33 subjects were analyzed. Consumption of corn syrup solids containing maltobionic acid was maintained; DPD and u‐NTx values were improved (p < .05). These results indicate that corn syrup solids containing maltobionic acid might contribute to suppress bone resorption and improve bone metabolism in postmenstrual women. (UMIN‐CTR ID: UMIN000034257; Foundation: San‐ei Sucrochemical Co., Ltd.).
Highlights
According to the NIH, osteoporosis is “A disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk” (NIH Consensus Development Panel, 2001)
It has been reported that an imbalance in bone metabolism, where an increase in bone resorption by osteoclasts overtakes bone formation, leads to a decrease in bone density and an increased risk of osteoporosis, and drives the risk of additional diseases, such as rheumatoid arthritis (Haugeberg, Uhlig, Falch, Halse, & Kvien, 2000) and periodontitis (Mohammad, Hooper, Vermilyea, Mariotti, & Preshaw, 2003; Penoni et al, 2016)
The following exclusion criteria were used to select the final study participants by excluding those with: (a) a medical history of osteoporosis, malignant tumor, heart failure, or myocardial infarction; (b) the presence of other diseases; (c) the regular use of pharmaceuticals or supplements; (d) the regular ingestion of foods for specialized health use or with functional claims; (e) weekly ingestion of calcium, vitamin D, vitamin K, magnesium, isoflavones and all other supplements, foods for specialized health use, foods with functional claims, and foods with nutritional function claims that could affect bone metabolism; and (f) allergies
Summary
According to the NIH, osteoporosis is “A disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk” (NIH Consensus Development Panel, 2001). In the ultra-aging society of Japan, the number of patients with osteoporosis has been increasing year by year with current estimates suggesting that 12.8 million Japanese citizens over 40 years old are affected, 70% of whom are women (Yoshimura et al, 2010, 2009). It has been reported that an imbalance in bone metabolism, where an increase in bone resorption by osteoclasts overtakes bone formation, leads to a decrease in bone density and an increased risk of osteoporosis, and drives the risk of additional diseases, such as rheumatoid arthritis (Haugeberg, Uhlig, Falch, Halse, & Kvien, 2000) and periodontitis (Mohammad, Hooper, Vermilyea, Mariotti, & Preshaw, 2003; Penoni et al, 2016). In addition to keeping the bone healthy, suppression of excessive bone resorption is important for maintaining quality of life (QOL) (Silverman, Minshall, Shen, Harper, & Xie, 2001)
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