Abstract
1. 1. Intradermal or subplantar injection of soluble snake venom phospholipase A 2(PLA 2) evoked a brisk inflammatory response, with cutaneous vascular permeability increase and paw oedema. 2. 2. These inflammatory processes are mainly the result of arachidonic acid cascade activation and mast cell degranulation. 3. 3. Copper, iron and zinc have an inhibitory effect on vascular permeability increase and paw oedema induced by PLA 2. 4. 4. Copper and iron could have not only a direct effect on PLA 2 but on enzymes of arachidonic acid cascade. 5. 5. However, zinc have a moderate antiinflammatory activity. This effect could be the result to inhibit PLA 2 induced mast cell degranulation.
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