Abstract
Abstract Effects of copper and hydrocortisone on the proliferation of cultured fibroblasts from macular mouse, a model of Menkes kinky hair disease, were analyzed by flow cytometry. In fibroblasts from the macular mouse, copper induced cytotoxicity and S‐phase accumulation of cell cycle were observed at lower concentrations of copper than in fibroblasts from the controls. However, the fibroblasts cultured with a combination of copper and hydrocortisone revealed recruitment of cell cycle. These results suggest that the proliferative activity of the cells from a macular mouse are more vulnerable to an excess amount of copper than normal, and that supplementation of hydrocortisone is effective for the Menkes kinky hair disease.
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