Abstract
Dorsal microcirculatory chambers (DMCs) were surgically implanted in the backs of rats to expose, beneath a transparent coverslip, the skeletal muscle microvasculature under the skin; two studies were completed using this model. In one study, microvascular perfusion was monitored for 96 h with laser Doppler fluxmetry and laser Doppler perfusion imaging to measure microvascular perfusion before and after contusion of the skeletal muscle within the DMC. There were statistically significant differences in microvascular perfusion observed with laser Doppler fluxmetry (baseline vs. postcontusion at 48 h) and with the scanning laser Doppler perfusion imager (baseline vs. postcontusion at 96 h). The second study monitored changes in microvascular perfusion following 20 min of local ice application to the back side (fur and skin side) of the DMC. Ice application resulted in a statistically significant reduction in microvascular perfusion as demonstrated by both laser Doppler instruments. The use of the two laser Doppler instruments with this model of skeletal muscle microcirculation provides direct measurements of microvascular perfusion that can be used to monitor the effect of contusion and cryotherapy on skeletal muscle microcirculation.
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