Effects of contrast medium on the pancreatic pathology in severe acute pancreatitis experiment with rats

Abstract

To investigate the effects of contrast medium on the pancreatic pathology in severe acute pancreatitis (SAP). Twenty-four Wistar rats underwent injection of sodium taurocholate into the biliopancreatic duct to establish models of SAP and then randomly divided into 4 groups: Group A (SAP group), Group B (SAP models injected with normal saline injected group), Group C (SAP models with injection of 76% castrografin), and Group D (SAP models injected with ultravist-300). Another 6 rats were used as blank controls. The rats were killed to undergo pathological examination of their pancreases. Modified Schmidt method was used to score the pathological changes. The modified Schmidt scores of Groups A, B, C, and D were (6.5 +/- 1.2), (7.7 +/- 1.0), (7.5 +/- 1.5), and (7.2 +/- 1.2) respectively, all significantly higher than that of the control group [(3.2 +/- 1.7), all P < 0.05]. However, there was no significant difference among these 4 groups (all P > 0.05). CM has no adverse effects on the pathology of pancreas with SAP and does not worsen the disease.