Abstract
Introduction: Mucoepidermoid carcinoma (MEC) is a common salivary gland malignancy. As studies reported on large cases of mucoepidermoid carcinoma of the parotid glands are few, this paper aims to research the effects of clinical and pathological factors, such as applying concentrated growth factor (CGF) on repairing and cervical lymph node metastasis, on the prognosis of mucoepidermoid carcinoma of the parotid gland.
 Methods: The retrospective analysis of prognostic factors was conducted based on 176 cases with mucoepidermoidcarcinoma of the parotid gland, who received treatment at the Affiliated Hospital of Chengde Medical College during the period of March 2000 to March 2012.
 Results: The Five-year overall survival rate was 75.57%, while the Five-year tumor-free survival rate was 64.77%. Univariate analysis showed that the influential factors for the prognosis of mucoepidermoid carcinoma of the parotid gland included surgical approach, tumor size, clinical stage, pathological grade, lymph node metastasis, and distant metastasis, etc; among which pathological grade, lymph node metastasis, and distant metastasis were indicated by multivariate analysis to be the independent risk factors.
 Conclusion: The survival rate of mucoepidermoid carcinoma of the parotid gland is relatively high. Lymph node metastasis, pathological grade, and distant metastasis are the independent risk factors that affect the prognosis of patients with mucous epidermis carcinoma of the parotid gland.
Highlights
Mucoepidermoid carcinoma (MEC) is a common salivary gland malignancy
The clinical staging was made according to the 2002 classification of the International Union Against Cancer (UICC 2002), and the diagnosis of MEC was made through clinical examination combined with magnetic resonance imaging (MRI) or computed tomography (CT) as follows: 29 patients presented with clinical stage I, 50 patients in stage II, 36 patients in stage III, and 61 patients in stage IV
Multivariate survival analysis: Multivariate analysis affecting prognosis was based on univariate Cox regression results, and incorporated clinical stage, lymph node metastasis, tumor size, surgical approach, distant metastasis, and pathological grade into further multivariate Cox regression analysis
Summary
Mucoepidermoid carcinoma (MEC) is a common salivary gland malignancy. As studies reported on large cases of mucoepidermoid carcinoma of the parotid glands are few, this paper aims to research the effects of clinical and pathological factors, such as applying concentrated growth factor (CGF) on repairing and cervical lymph node metastasis, on the prognosis of mucoepidermoid carcinoma of the parotid gland. Mucoepidermoid carcinoma (MEC) is the most common malignant tumor in salivary glands, accounting for 3% -15% of all salivary gland tumors, of which 62% occur in the parotid glands.[1] In recent years, the incidence of MEC of the parotid glands shows rising and younger trends.[2] As researches on large cases of mucoepidermoid carcinoma of the parotid glands are rarely reported, this study retrospectively analyzed the clinicopathological data of 176 cases with parotid MEC, and explored the relevant factors affecting its prognosis. Concentrated growth factor (CGF) is a gel-like mass containing high concentrations of various growth factors and fibrin isolated from autologous blood by centrifugation and has the function of promoting tissue regeneration.[3] It can promote tissue healing and reduce postoperative scars.[4]
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