Abstract
Using the model of acute myocardial ischemia in rats formed by ligation of the descending anterior branch of the left coronary artery, this study showed some effects of compound Salviae miltiorrhizae injection (CSMI) on metabolism of phosphoinositide in myocardial ischemia. The results of the experiment showed that after 10 minutes of acute ischemia, the function of myocardial messangers of phosphoinositide increased, and the levels of phosphatidylinositol-4, 5-biphosphate (PIP2) and inositol-1, 4, 5-trisphosphate (IP3) were obviously higher than those of the non-ischemia control groups (P<0.01, n=7). CSMI (2 g/kg body weight) could markedly inhibit myocardial PIP2 and IP3, whose levels became lower than those of the ischemia control groups (P<0.01, n=7).
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