Effects of compound Danshen dripping pills on brain natriuretic peptide level and ventricular remodeling after percutaneous coronary intervention in patients with acute myocardial infarction

Abstract

Objective To study the effects of compound Danshen dripping pills on brain natriuretic peptide(BNP) level and ventricular remodeling after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods A total of 150 patients with AMI who underwent PCI in the People’s Hospital of Xinzhou from February 2015 to February 2018 were randomly divided into experimental group and control group according to the random number table method, with 75 cases in each group. The patients in the control group were given routine treatment (oxygen inhalation, subcutaneous injection of low molecular weight heparin), while the patients in the experimental group were given compound Danshen dripping pills orally on this basis of treatment of control group. The plasma BNP concentration and ventricular remodeling indexes including left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF) were compared between the two groups 24 h and 1 month after operation. The peripheral blood white blood cell count (WBC) and serum C-reactive protein (CRP) were recorded in the two groups 24 h and 1 week after operation. Results At 1 month after operation, the plasma BNP levels in the two groups were lower than those at 24 h after operation, and the decrease of BNP concentration in experimental group was more significant than that in control group (P all 0.05). However, the LVEF level was higher than that at 1 week after operation, and the index in experimental group was higher than that in control group (P all <0.05). At 1 week after operation, the WBC and CRP in the two groups were decreased compared with those at 24 h after operation, and the decreases were more significant in experimental group ( P all<0.05). Conclusions Compound Danshen dripping pills can alleviate inflammation and reduce BNP level in patients with AMI after PCI. It can improve symptoms and prevent ventricular remodeling. Key words: Compound Danshen dripping pills; Acute myocardial infarction; Percutaneous coronary intervention; Brain natriuretic peptide; Ventricular remodeling