Abstract
Active peptides have good effectiveness in controlling or preventing many diseases. Compound active peptides (CAP) obtained from animal, plant, and sea food proteins were used in this study to explore their effects on antioxidation, anti-inflammation, and antihyperglycemia in vitro and in vivo. The results demonstrated that 10 μg/mL CAP could increase cell viability (P < 0.05) and decrease reactive oxygen species (ROS) levels and cell apoptosis (P < 0.05) when WRL68 cells were induced by H2O2 for 6 h. Moreover, incubation with 20 μg/mL CAP for 6 h significantly increased cell viability and Bcl-2 expression level (P < 0.05) and decreased expression levels of IL-6, IL-8, TNF-α, Bax, and Caspase 3 and the ratio of Bax/Bcl-2 (P < 0.05) when swine jejunal epithelial cells (IPEC-J2) were induced by deoxynivalenol (DON). In addition, adding CAP individually or combined with Liuweidihuang pills (LDP, Chinese medicine) and low-dose glibenclamide could lower blood glucose levels in alloxan-induced hyperglycemic model mice. These results suggested that CAP was probably a beneficial ingredient for alleviating H2O2-induced oxidative stress and DON-induced cell inflammation and apoptosis and preventing hyperglycemia.
Highlights
Active peptides defined as specific regions of proteins with a part of 20 natural amino acid sequences in a certain order and structure have certain biological or physiological effects
Active peptides are extremely abundant in many resources, which can be extracted from animal or plant proteins such as wheat, rice, soybean, egg, and sea food [1,2,3]
The model group treated with 200 μmol/L
Summary
Active peptides defined as specific regions of proteins with a part of 20 natural amino acid sequences in a certain order and structure have certain biological or physiological effects. Diverse types and orders of amino acids determine their extensive functions. Active peptides are extremely abundant in many resources, which can be extracted from animal or plant proteins such as wheat, rice, soybean, egg, and sea food [1,2,3]. Active peptides are generally named after their ingredient types, for example, soybean peptide, rice bran peptide, peanut peptide, sea cucumber peptide, and oyster peptide. In order to increase the effectiveness of CAP, many kinds of active peptides extracted from oysters, sea cucumbers, soybean, and other organisms were selected and mixed together in this study
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