Abstract
Aging-associated changes of skin conditions are a major concern for maintaining quality of life. Therefore, the improvement of skin conditions by dietary supplementation is a topic of public interest. In this study, we hypothesized that a composite supplement containing fish derived-collagen peptide and ornithine (CPO) could improve skin conditions by increasing plasma growth hormone and/or insulin-like growth factor-1 (IGF-1) levels. Twenty-two healthy Japanese participants were enrolled in an 8-week double-blind placebo-controlled pilot study. They were assigned to either a CPO group, who were supplemented with a drink containing CPO, or an identical placebo group. We examined skin conditions including elasticity and transepidermal water loss (TEWL), as well as plasma growth hormone and IGF-1 levels. Skin elasticity and TEWL were significantly improved in the CPO group compared with the placebo group. Furthermore, only the CPO group showed increased plasma IGF-1 levels after 8 weeks of supplementation compared with the baseline. Our results might suggest the novel possibility for the use of CPO to improve skin conditions by increasing plasma IGF-1 levels.
Highlights
The major role of skin is the protection of our body from external stimuli
Study is the first demonstrate thethat combined of collagen peptide and ornithine (CPO) on skin conditions, plasma our growth hormone andreport
We found dietaryeffects supplementation skin conditions, plasma growth hormone and insulin-like growth factor-1 (IGF-1) levels
Summary
The major role of skin is the protection of our body from external stimuli. Skin plays an important role in maintaining homeostasis, including protection against loss of moisture and adjustment of body temperature [1]. Collagen and elastin in the dermis maintain the structure of skin and create its elasticity [2,3]. The fibrous protein collagen, which plays a major role in maintaining the mechanical strength of skin, constitutes the majority of the dermis. The collagen molecule is formed by the three polypeptides, named alpha chains. These collagen molecules assemble to form collagen fibrils by cross linking. Collagen fibrils assemble to form large collagen fiber. Because collagen synthesis decreases with aging, decreased collagen content is one of the major causes of
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
