Effects of Complex Treatment by Use of Fetal Stem Cells on Bone Mineral Density in Postmenopausal Women

Abstract

Analysis of bone mineral density index and a 10-year risk of fractures have been performed and two groups of postmenopausal women under the study were compared. Both investigated groups were randomized and conventional therapy by use of medicines including peroral administration of vitamin D3 and bisphosphonate were prescribed due to special indication. In treatment of the main group (MG), women along with standard therapy methods had been receiving treatment by use of fetal stem cells (FSCs). In accordance with the results and comparison between the groups, bone mineral density of femoral neck and trochanter became significantly higher in the group of women who underwent combined treatment with FSCs if compared to the control group (CG). Furthermore, in the MG we noted a tendency to downgrading a 10-year risk of fractures development in postmenopausal women, if compared to the CG upon randomization, where the patients received only a traditional treatment using medicines. This research aims to investigate effectiveness of complex therapy with FSCs derived from 7 to 12-week gestation fetuses and comparing such a treatment influence on certain markers of ageing process in postmenopausal women between the MG and the CG of patients. Criteria for comparing suggested a study of bone mineral density (BMD), as well as 10-year risk of fractures by Fracture Risk Assessment Tool (FRAX), which are the markers of agerelated changes of the skeletal system in women.