Abstract
To investigate the frequency of Comorbid Fibromyalgia Syndrome and its effects on quality of life and activities of daily living without any known psychiatric problem (schizophrenia or bipolar disorder) or severe disability, other than depression, in patients with multiple sclerosis, which is known to be a chronic disease in young adults. The study included 103 patients diagnosed with multiple sclerosis, following McDonald criteria, who had relapsing remitting disease. The Fibromyalgia Impact Questionnaire, Beck Anxiety Inventory, Beck Depression Inventory, Pittsburgh Sleep Quality Index, Fatigue Severity Scale, and Multiple Sclerosis Quality of Life-54 were applied for all patients. Results were analyzed using statistical methods. Mean age was 35.04±8.72 years in the study population. The Expanded Disability Status Scale (EDSS) score was 2.21±0.93. Comorbid Fibromyalgia Syndrome was detected in 20 patients (19.4%). The mean score of Multiple Sclerosis Quality of Life-54 was found to be significantly higher in multiple sclerosis patients with Comorbid Fibromyalgia Syndrome when compared to those without it (34.80±9.14 versus 71.67±13.95; p<0.05). These results indicate that increased frequency of Comorbid Fibromyalgia Syndrome in multiple sclerosis causes worsening in activities of daily living and quality of life, delayed diagnosis, disability progression, and increased admission rates. Questioning and appropriately managing Comorbid Fibromyalgia Syndrome in clinical practice are important to improve the quality of life in multiple sclerosis patients.
Highlights
Multiple sclerosis (MS) is an autoimmune, inflammatory, demyelinating, and neurodegenerative disorder that has been more commonly seen in women, which is characterized by relapsing neurological dysfunction
It has been reported that physical disorders, such as fibromyalgia syndrome (FMS), and psychiatric disorders, such as depression and anxiety disorders, euphoria, fatigue, sleep disorder, bipolar disorder and schizophrenia are frequently seen in MS patients who have been exposed to severe physical and psychosocial stressors
This study aimed to investigate the frequency and effects of FMS on activities of daily living (ADL) without known psychiatric problem or severe disability in patients with MS, which is known to be a chronic disease in young adults
Summary
Multiple sclerosis (MS) is an autoimmune, inflammatory, demyelinating, and neurodegenerative disorder that has been more commonly seen in women, which is characterized by relapsing neurological dysfunction. FMS is a clinical condition that presents many symptoms, such as chronic, widespread pain and fatigue, sleep disorder, cognitive dysfunction, and depressive episodes[6]. Quality of life is impaired due to physical and psychological disorders caused by FMS, which is associated with widespread pain (hyperalgesia and/or allodynia), tenderness in certain anatomic regions (tender points), chronic fatigue, sleep disorder, rigidity, and subjective swelling. This study aimed to investigate the frequency and effects of FMS on activities of daily living (ADL) without known psychiatric problem or severe disability in patients with MS, which is known to be a chronic disease in young adults
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