Abstract
To determine the effects of commonly used commercial skin lightening creams on the thickness of epidermis of guinea pig skin. Animal experimental study. Department of Anatomy, King Edward Medical University, Lahore, from March to May 2015. Forty-eight adult, colored guinea pigs were used in this study. The animals were randomly divided into four groups. Group I was control group (no cream application). The animals of group II, III and IV were treated with skin whitening creams A, B and C respectively once daily, 6 days/week for eight weeks duration. The observations of skin specimens were made after 4 and 8 weeks for epidermal thickness at histological level. Microscopic examination showed variable degrees of epidermal thickening with the three creams applied for 4 weeks. The increase in thickness of epidermis ranged from 49.1 μm in control group to maximum of 106.4 μm in group ll. These effects were further intensified after 8 weeks application. The use of whitening creams caused skin damage by increasing the epidermal thickness of varying extent.
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Schedule a callMore From: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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