Abstract

Background: Transcranial Direct Current Stimulation (tDCS) combined with traditional rehabilitative techniques has not been widely applied to Rett Syndrome (RTT). The aim of this study was to examine the effects of combined cognitive traditional training with tDCS applied to attention and language measures in subjects with RTT. Methods: 31 subjects with RTT were randomly allocated into two groups: non-sham tDCS (n = 18) and sham tDCS (n = 13). The former received the integrated intervention non-sham tDCS plus cognitive empowerment during the treatment phase. The latter received sham stimulation plus cognitive empowerment. All participants underwent neurological and cognitive assessment to evaluate attention and language measures: before integrated treatment (pre-test phase), at the conclusion of the treatment (post-test phase), and at 1 month after the conclusion of the treatment (follow-up phase). Results: the results indicated longer attention time in the non-sham tDCS group compared to the sham tDCS group with a stable trend also in the follow-up phase; an increase of the number of vowel/phoneme sounds in the non-sham tDCS group; and an improvement in the neurophysiological parameters in the non-sham tDCS group. Conclusions: This study supports the use of tDCS as a promising and alternative approach in the RTT rehabilitation field.

Highlights

  • Rett syndrome (RTT) is a complex genetic disorder, caused by mutations in the X-linked gene encoding for a regulator of epigenetic gene expression, methyl CpG binding protein (MeCP2) [1,2]. mutations in MECP2 gene are the main cause of Rett Syndrome (RTT) disease, other mutations are associated with RTT, such as: FOXG-1 and CDLK-5 [3,4]

  • Mutations in MECP2 gene are the main cause of RTT disease, other mutations are associated with RTT, such as: FOXG-1 and CDLK-5 [3,4]

  • The main aim of this study was to examine the effect of combined Transcranial Direct Current Stimulation (tDCS) with cognitive training applied to attention and language abilities in subjects with RTT

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Summary

Introduction

Rett syndrome (RTT) is a complex genetic disorder, caused by mutations in the X-linked gene encoding for a regulator of epigenetic gene expression, methyl CpG binding protein (MeCP2) [1,2]. mutations in MECP2 gene are the main cause of RTT disease, other mutations are associated with RTT, such as: FOXG-1 and CDLK-5 [3,4]. Transcranial Direct Current Stimulation (tDCS) combined with traditional rehabilitative techniques has not been widely applied to Rett Syndrome (RTT). The aim of this study was to examine the effects of combined cognitive traditional training with tDCS applied to attention and language measures in subjects with RTT. Methods: 31 subjects with RTT were randomly allocated into two groups: non-sham tDCS (n = 18) and sham tDCS (n = 13). The former received the integrated intervention non-sham tDCS plus cognitive empowerment during the treatment phase. The latter received sham stimulation plus cognitive empowerment. Results: the results indicated longer attention time in the non-sham tDCS group compared to the sham tDCS group with a stable trend in the follow-up phase; an increase of the number of vowel/phoneme sounds in the non-sham tDCS group; and an improvement in the neurophysiological parameters in the non-sham tDCS group

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