Abstract
Purpose. To determine if a sustained reduction in of plasma leptin concentration causes an alteration in the protein expression level of its receptors in human skeletal muscle.Methods. Fifteen males ((mean ± SD), age: 35 ±5.1 years; height: 176 ±3.6 cm; body mass: 79.2 ± 7.4 kg and percentage of body fat 22.6 ± 5.4%) participated in a 12‐week weightlifting training program. Pre and post‐training muscle biopsies were obtained from the m. vastus lateralis to determine the expression of the leptin receptor (OB‐R) protein isoforms by Western blot (J Appl Physiol. 2007 102:1786–92). Body composition was determined by DXA.Results. Training resulted in lower percentage of body fat was (from 22.5 ± 5.4 to 21.1 ±3.7 %, P = 0.06) and leptin concentration (from 9.0±7.7 to 5.7±3.7 ng/mL, P<0.05). The changes in leptin serum concentration correlated with the changes in the percentage of body fat mass (r = 0.66, p<0.05). However, non‐significant changes were observed in the expression level of the 170KDa isoform of the LR (0.77±0.2 vs. 0.85±0.5, P = 0.499) nor in the 128KDa (0.50±0.57 vs. 0.68±0.72, P=0.372) and 98KDa isoforms (1.75±1.27 vs. 1.76±2.08, P= 0.984) in skeletal muscle.Conclusion. Skeletal muscle OB‐R expression is not modified by strength training, despite a reduction in fat mass and serum leptin concentration. These findings are compatible with increased leptin sensitivity after strength training.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
