Effects of Collagen and Collagen Hydrolysate from Jellyfish Umbrella on Histological and Immunity Changes of Mice Photoaging

Jian Fan,Yongliang Zhuang,Bafang Li

doi:10.3390/nu5010223

Jian Fan, Yongliang Zhuang + Show 1 more

Open Access

https://doi.org/10.3390/nu5010223

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Abstract

Jellyfish collagen (JC) was extracted from jellyfish umbrella and hydrolyzed to prepare jellyfish collagen hydrolysate (JCH). The effects of JC and JCH on UV-induced skin damage of mice were evaluated by the skin moisture, microscopic analyses of skin and immunity indexes. The skin moisture analyses showed that moisture retention ability of UV-induced mice skin was increased by JC and JCH. Further histological analysis showed that JC and JCH could repair the endogenous collagen and elastin protein fibers, and could maintain the natural ratio of type I to type III collagen. The immunity indexes showed that JC and JCH play a role in enhancing immunity of photoaging mice in vivo. JCH showed much higher protective ability than JC. These results suggest that JCH as a potential novel antiphotoaging agent from natural resources.

Highlights

UV radiation is the main cause of skin damage, which includes photoaging, local and systemic immunosuppression, and photocarcinogenesis [1]
UV radiation interacts with cellular chromatophores and photosensitisers, resulting in the generation of reactive oxygen species (ROS), DNA damage and Nutrients 2013, 5 activation of signaling pathways related to cell/tissue growth, differentiation, senescence and connective tissue degradation [2]
The results showed that Jellyfish collagen (JC) was mainly composed of α1 chains, which was similar to that of type I collagen of bovine

Summary

Introduction

UV radiation is the main cause of skin damage, which includes photoaging, local and systemic immunosuppression, and photocarcinogenesis [1]. The discovery and development of novel protective and therapeutic agents against UV-induced photodamage is critical for preventing and repairing the damaging effects of UVR in human skin. Antioxidants have been proven to be effective in the protection of skin against UV-induced damage in recent years. Some dietary antioxidants have shown potential chemoprophylactic activities, including chlamys farreri peptide [3], ferulic acid [4], and cod polypeptide [5]. Collagen is another newly founded antioxidant resource. Collagen hydrolysates, which are generally obtained by enzymatic proteolysis from collagen, have exhibited numerous bioactivities, including antioxidant activity, mineral binding capacity, antihypertensive activity, lipid-lowering effect, immunomodulatory activity, etc. The properties of collagen hydrolysates such as good bioactivity, biocompatibility, and penetrability as well as, reparative ability to skin, and less irritation make it a popular regent for developing skin care products [7]

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