Abstract
The effects of chronic cocaine exposure on dopamine D 1 and D 2 receptor gene expression in the human brain were studied in postmortem samples from chronic cocaine abusing and matched control subjects. Using in situ hybridization and receptor autoradiography to examine messenger ribonucleic acid (RNA) and binding sites, respectively, neither D 1 nor D 2 receptor expression was found to be changed in the nucleus accumbens, caudate, putamen, or substantia nigra of the cocaine-exposed subjects. Although chronic cocaine exposure can produce alterations in dopaminergic neurotransmission, sustained compensatory changes in dopamine receptor expression do not appear to occur in the human.
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