Abstract
Changes in the hepatocytes of rats treated with the hypolipidemic agent clofibrate for a 1 week period were investigated. During this time liver weight increased while, in contrast to peroxisomes, mitochondrial and microsomal protein were not changed significantly. While there was no effect on cytochrome oxidase activity carnitineacetyl transferase activity increased more than 20-fold. The urate oxidase activity of the homogenate decreased about 30% and palmitoyl-CoA oxidation increased more than 10 times. The ratio of protein to phospholipid in microsomes was not affected, nor were the rates of incorporation of [ 3H]leucine, [ 3H]glycerol and [ 3H]mevalonate into total protein, phospholipid and cholesterol, respectively. Injection of labeled glucosamine, mannose and galactose into the animals revealed an increased incorporation of these substances into lipid intermediates and endogenous luminal and membranous protein acceptors after clofibrate treatment. The significant stimulation of enzymes participating in hydroxylation reactions may be the main reason for the complex cellular changes brought about by clofibrate.
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