Effects of Citicholine on respiration rate, Spo2, heart rate and rectal temperature during Thiopental intravenous anaesthesia in Canine model

Abstract

Thiopental Sodium is an ultra short-acting barbiturate. Due to its redistribution characteristic, its first injection has a short term effect. In order to elongate its anesthesia duration, more injections are needed. As these additional injections extend the recovery length , weaken respiration and causes other dangerous effects; its repeated use is considered unsafe. Citicoline is a natural substance with neuroprotective effects. Regarding the various effects of citicoline on central nervous system which is the place where many anesthetics leave their effects, this research aims at studying the effects of citicoline on the anesthesia induced by Thiopental Sodium and also at Measuring the parameters such as heart and respiration rate,rectal temperature and SPO2. To do this,6 dogs were anesthetized by intravenous injection of 20 mg ∕ kg of 2.5% Thiopental sodium . After the appearance of recovery signs, 250 mg of citicoline was slowly injected intravenously into the experimental dogs, and immediately the second injection of Thiopental sodium using the initial protocol was given. Before the second injection, 2ml of normal saline was intravenously injected into the dogs in the control group.Heart and respiration rate ,SPO2 and rectal temperature were then measured,recorded and statistically analyzed.Results indicated a significant increase in heart and respiration rate,an insignificant increase in SPO2 and an insignificant decrease of rectal tempreture in animals that had received citicolin before anesthesia by Thiopental Sodium.The results of this study can be used in predicting the vital signs of patients when taking these two drugs simultaneously.