Abstract
Cis-dichloro-diammine-platinum(II) has been shown to be a potent antitonor agent effective against a number of animal tumors. A possible mechanism of its action through an enhanced antigenicity or the enhanced cellular immune system has already been proposed. Present studies outline the direct cytotoxic effects of Cis-Pt(II)(NH3)2Cl2 on Sarcoma-180 ascites cells, Human lymphoma cells and Human AV3 cells in absence of the hostdefense mechanisms.Majority of Sarcoma-180 ascites cell population consists of lightly staining cells with a few dark cells, macrophages and polymorphic leukocytes. The cellular organelles are randomly distributed in the cytoplasm (Fig. 1). The large rounded or oval mitochondria have dense matrix and the cisternae of the RER are usually 600-1000 Å wide. 60-70 Å thick microfilaments are present through out the cell and often concentrate in the perinuclear region associating with the outer nuclear membrane.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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