Abstract
Oxidative stress seems to be involved in the development and maintenance of renovascular hypertension. The aim of the present study was to evaluate the effects of chronic administration of an antioxidant ‐ vitamin C (VitC) ‐ on arterial blood pressure (AP), baroreflex control of heart rate (HR) and on renal sympathetic nerve activity (RSNA) in the two kidney one clip hypertension (2K‐1C) model. Control and 2K‐1C male Wistar rats were treated with two different doses of VitC (150 and 250mg/kg/day) by gavage for seven days. VitC 150mg/kg decreased basal AP in 2K‐1C (23±7mmHg, n=13) as well as in control (C: 12±3mmHg, n=12) rats, with no changes in HR. In contrast, VitC 250mg/kg did not reduce significantly AP; however, there was a tendency of reduction in both groups. The baroreflex control of HR and RSNA was evaluated by bolus injection of phenylephrine. Both doses of VitC increased baroreflex sensibilitiy for bradicardic responses (C+Vit C150: 58%, n=6; 2K‐1C+VitC150: 47%, n=9; C+VitC250: 49%, n=8; 2K‐1C+VitC250: 128%, n=7) and RSNA (Cl+VitC150: 62%, n=6 and 2K‐1C+VitC150: 153%, n=6). Taken altogether, the present study suggests a possible role of oxidative stress in the baroreflex dysfunction in renovascular hypertension. Apparently, the actions of VitC on baroreflex control and on AP responses are independent. Supported by FAPESP.
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