Abstract
Epidemiological studies have shown that chronic sleep disturbances resulted in metabolic disorders. The purpose of this study was to assess the relationship between chronic sleep deprivation (CSD) and the glucose homeostasis in rats. Twenty-four rats were randomly divided into CSD group and control (CON) group. The CSD rats were intervened by a modified multiple platform method (MMPM) to establish an animal model of chronic sleep disturbances. After 3-month intervention, all rats were subjected to an intraperitoneal glucose tolerance test (IPGTT) and an insulin tolerance test (ITT), and the body weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, lipid profile group, and homeostasis model assessment-IR (HOMA-IR) were measured. Both the CSD and CON groups had an attenuation of weight gain after 3-month intervention. The plasma glucose level of CSD group was higher than that of the CON group during the IPGTT (P < 0.01). The CSD rats showed a marked increase in HOMA-IR and ITT compared with the CON group (P < 0.01). There were no significant differences of AST, ALT, creatinine, and most lipid parameters between the CSD and CON groups (P > 0.05). The CSD has a marked effect on glucose homeostasis, comprising glucose intolerance and insulin resistance.
Highlights
Lack of sleep, especially frequent or chronic sleep disturbances, has become a worldwide health problem, drawing increasingly attention in the modern society
After 3-month intervention, all rats were subjected to an intraperitoneal glucose tolerance test (IPGTT) and an insulin tolerance test (ITT), and the body weight, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, lipid profile group, and homeostasis model assessment-IR (HOMA-IR) were measured
The areas under the curves (AUC) of receiver operating characteristic (ROC) curves for ITT between the chronic sleep deprivation (CSD) and CON group was significantly different (Fig. 3b, P \ 0.01). These present results demonstrate that the CSD, leading to both short sleep duration and poor sleep quality, has an important effect on glucose homeostasis in rats
Summary
Especially frequent or chronic sleep disturbances, has become a worldwide health problem, drawing increasingly attention in the modern society. It has been reported that the average sleep duration has decreased from about 9 h per night in 1910 to about 7.04 h presently, and 58 % of people had sleep problems [1, 2]. For the factors of increases in environmental light, longer work days/longer commuting time, an increase in evening and night work, availability of media, and late nocturnal sleep onsets, more people would suffer from chronic sleep deprivation (CSD) [3, 4]. The CSD, leading to both short sleep duration and poor sleep quality, has important consequences for an individual’s well-being [5,6,7]. In the case of CSD, either short sleep duration or poor quality sleep could affect the neurobiological regulation of circadian rhythm, increasing much burden on the regulatory systems to maintain allostasis [8].
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