Abstract
Rats were treated with lead via the mother's milk from birth to weaning. After a lead-free period of approximately 4 months, responses to norepinephrine were tested. Neither the pressor effect nor the enhancement of myocardial cAMP accumulation caused by norepinephrine was altered by prior lead treatment. However, norepinephrine caused significantly more cardiac arrhythmias in lead-treated animals than in controls. Even doses of norepinephrine which caused no significant ECG abnormalities in control animals were arrhythmogenic in lead-treated rats. It is concluded that lead treatment causes changes in cardiac conduction which are not readily reversed by termination of lead exposure.
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