Abstract
To evaluate the effects of GT and purified GTE treatment in hypertension, male Wistar rats were treated orally for 2 weeks with L‐Name, 20 mg/Kg/day). By the end of the first week of treatment, the animals were divided in: L‐Name treated; L‐Name + GT (9,6g/L) and L‐Name + GTE (20 mg/Kg/day). The same treatment was performed in control normotensive animals. By the end of treatment period blood pressure (BP) and heart rate (HR) were directly measured. Baroreflex sensitivity was evaluated by changes in BP elicited by IV infusion of phenylephrine or sodium nitroprusside and reflex HR responses. Water/tea ingestion and urinary volume were also evaluated for 24h. L‐Name treated rats (188±11 mmHg) had a significant increase in BP compared to control group (103±5 mmHg) and treatment with GT (123±6 mmHg) or GTE (132±2 mmHg) promoted a significant reduction in this parameter. It was also observed an improvement in baroreflex sensitivity in treated rats. There was no statistically difference among groups in urinary or intake volume. Treatment with GT and GTE presented an important antihypertensive effect associated with improvement in baroreflex control, and independently of a diuretic effect.Supported by CAPES and Cnpq.
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