Abstract
The effect of a benzodiazepine, flurazepam, on the spontaneous activity of neurons in the pars reticulata of the substantia nigra was studied in chloral hydrate anesthetized rats. Flurazepam produced a dose-related suppression of neuronal activity. In rats that were chronically treated with flurazepam, tolerance to flurazepam was present after 7 and 28 days, but not after only 3 days of treatment. Tolerance persisted at least 2, but not 7 days after 4 weeks of chronic treatment.
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