Abstract
Since the neuroactive steroid 3α,5α-tetrahydroprogesterone (3α,5α-THP) has pharmacologic actions similar to benzodiazepine agonists such as diazepam, the influences of chronic diazepam exposure on stress-induced brain levels of 3α,5α-THP were examined. Groups of male, female, orchidectomized (ORCH), and ovariectomized (OVX) rats were compared, along with OVX groups given hormone replacement. Chronic diazepam exposure diminished stress-induced brain levels of 3α,5α-THP and serum corticosterone, although gender, gonadectomy and hormone replacement had disparate influences on these two endocrine responses to stress.
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