Abstract
Effects of cholinergic agents and their blockers on adrenaline secretion from rat adrenal were investigated. Nicotine-induced adrenaline output was markedly prevented by hexamethonium. High doses of atropine (1·0 mg/kg, i.v.) also decreased nicotine-induced adrenaline secretion from splanchnicotomized adrenal. Acetylcholine (ACh) subsequent to neostigmine caused marked secretion of adrenaline, which was almost completely blocked by atropine pretreatment. However, ACh-induced adrenaline output from the splanchnicotomized adrenal was much less than that from the intact gland. The response of chronically and completely denervated adrenal to ACh was larger than that of the chronically or acutely splanchnicotomized gland. Pilocarpine increased adrenaline secretion and the output was prevented by pretreatment with atropine. In acutely splanchnicotomized rats, pilocarpine caused little increase of adrenaline secretion. Atropine (1·0 mg/kg, i.p.) caused a slight increase of adrenaline output in response to ether anesthesia, although methylatropine tended to inhibit output. Stimulation of the central end of the severed vagus at the cervical level had no effect on adrenaline liberation from splanchnicotomized adrenal with or without stimulation of splanchnic nerve. From these results, the sites of action of these drugs in rats are discussed.
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