Abstract
Subcutaneous injection of apomorphine in small doses decreased, while larger doses increased motility in rats. The hypomotility was abolished by intracerebroventricular administration of sulphated cholecystokinin octapeptide [CCK-8(s)], but not by non-sulphated CCK-8 [CCK-8(ns)]. In contrast, the hypermotility was not influenced by CCK peptides. An antiserum directed against the C-terminus of CCK did not affect hypermotility induced by apomorphine but suppressed the apomorphine-induced hypomotility further. The results indicate that sulphated CCK-peptides contribute to the control of motility, which can be inhibited by apomorphine.
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