Effects of cholecystokinin and calcitonin on evoked brain potentials and satiety in man

Abstract

Central nervous effects of the peptides cholecystokinin (CCK) and calcitonin (CT) were tested in an attention task for their effects on Auditory Event Related Potentials (AERPs) and for their effects on satiety and activation as measured in self-rating scales. Thirteen healthy subjects received either 3 IDU/kg body weight CCK 1–33, 0.1 IU/kg bodyweight CT and placebo according to a double-blind within-subject cross-over design. Subjects had fasted for at least 16 hr prior to the experiment. CCK induced the feeling of satiety after stimulation with the preparation of a meal. The peptides prevented an attenuation of the N2-component of the AERP after the preparation of a meal, indicating that the subjects were less distracted by the food cues. The results suggest that the central nervous effects of CCK and CT may constitute an aspect of satiated behavior.