Abstract
Twenty-four Angus steers (365 kg ± 4) were assigned randomly to a 2 × 2 factorial arrangement of treatments of either 0 or 350 mg chlortetracycline d-1, with or without Synovex-S to test the effects of chlortetracycline (CTC) and estrogenic implant on release of growth hormone (GH) and thyroid hormones. Steers received ad libitum a concentrate-forage diet over a 112-d feeding study, and growth and carcass characteristics were determined. On days 30, 56, and 106, steers received an injection, via jugular catheter, of 1.0 µg kg-1 BW thyrotropin-releasing hormone (TRH) + 0.1 µg kg-1 BW GH-releasing hormone (GHRH) and blood was collected from -30 to 360 min post-injection. Overall, compared with non-implanted steers, Synovex-S increased (P ≤ 0.009) rate and efficiency of gain, decreased (P = 0.05) time to peak for GH concentrations, whereas baseline concentrations of thyroid-stimulating hormone (TSH) were increased (P = 0.03). Additionally, the TSH response curve (P ≤ 0.05) and magnitude of triiodothyronine (T3; P = 0.01) response were greater following TRH + GHRH challenge for implanted versus nonimplanted steers. There were no main effects of CTC; however, CTC attenuated (P ≤ 0.05) the effects of implant on T3 release, slaughter weight, and carcass composition. In conclusion, Synovex-S alone increased BW gain and enhanced the response of GH, TSH, and T3 to a TRH + GHRH challenge, whereas CTC alone did not affect rate and composition of gain or release of pituitary and thyroid hormones. However, CTC appeared to mitigate the effects of implant on T3 release and carcass composition. Key words: Growth hormone, thyroid, estrogen, chlortetracycline, bovine, growth
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