Abstract
Using the conventional in vitro frog skin bioassay technique, it has been shown that chlorpromazine can have a direct as well as an indirect effect on frog dermal chromatophores and that chlorpromazine darkened skin loses its ability to react either by further darkening with ACTH or lightening in fresh frog Ringer's. Epidermal melanocytes are capable of reacting to chlorpromazine but must be in an almost totally contracted state to do so.
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