Effects of chlordiazepoxide upon successive red-green discrimination responses in Japanese monkeys, Macaca fuscata.

Abstract

Monkeys were trained on a successive go/no-go type red-green discrimination task for food following intramuscular saline. After reaching a 90% correct criterion, they were injected with 20 mg/kg of chlordiazepoxide (CDP) and then tested on the same successive task or on the simultaneous red-green discrimination task. CDP was found to disrupt waiting (no-go) response on the successive discrimination task, without affecting discrimination itself as shown by their perfect results on the simultaneous discrimination task. The result is interpreted in terms of the drug's disinhibitory effects.