Abstract
The enzymatic hydrolysates of chitosan with average molecular weights range from 5000 to 20000 and with low viscosity interfered with intestinal absorption of cholesterol in lymph fistulated rats and increased fecal excretion of neutral steroids in rats fed a cholesterol-enriched diet. The hydrolysates exerted a cholesterol-lowering activity, and it was more marked in the liver than in the serum. They also reduced liver triglyceride significantly. Chitosan hydrolysates with average molecular weights of 10000-20000 were as effective as high-viscous chitosan with a molecular weight of 50000. The results indicate usability of low-viscosity chitosan hydrolysate as a hypocholesterolemic agent.
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