Abstract
The Chinese herbal formula consisting of Astragalus membranaceus, Epimedium brevicornum, Paeoniae Alba Radix and Radix Ophiopogonis in proper proportions were adopted in order to investigate the immunoenhancing properties of the herbal formula. Fifty ICR mice were randomly divided into 5 groups (NS- NS+Hy-L+Hy-M+Hy-H+Hy ). The mice in hydrocortisone (Hy) groups were injected with hydrocortisone i.p. to induce the immunosuppressive condition. The mice in group NS were administered with normal saline as controls. The mice in groups NS+Hy-L+Hy-M+Hy-H+Hy were administered with normal saline, low, moderate and high dose of the herbal prescription respectively by gavage for 6 days. The level of serum hemolysin, the function of antibody function cell-AFC-and CD4⁺/CD8⁺ T cell ratio were measured at the end of experiments. The results showed that the level of serum hemolysin, the function of AFC and CD4⁺/CD8⁺ T cell ratio in L+Hy-M+Hy-H+Hy groups increased significantly compared with those in NS or NS+Hy groups. These results indicate that Chinese herbal medicine prescription can enhance humoral immunity and cellular immune function of the immunosuppressive mouse.
Highlights
With the development of molecular biology and immunopharmacology, Chinese herbal medicine immunology has become an important branch of modern medicine
The study of the effects of the herbal medicine formula composed of Astragalus membranaceus, Epimedium brevicornum, Paeoniae Alba Radix and Radix Ophiopogonis was carried out through measuring the serum hemolysin level, antibody function cells and the peripheral blood T-lymphocyte subsets of the immunosuppressive mice
The level of serum hemolysin was significantly decreased in the Hy group as compared to saline group
Summary
With the development of molecular biology and immunopharmacology, Chinese herbal medicine immunology has become an important branch of modern medicine. In recent years, immunomodulating properties and disease resistance of Chinese herbal medicines were investigated with a series of achievements (Ma, 2007; Chi and Wu, 2004). In this experiment, the study of the effects of the herbal medicine formula composed of Astragalus membranaceus, Epimedium brevicornum, Paeoniae Alba Radix and Radix Ophiopogonis was carried out through measuring the serum hemolysin level, antibody function cells and the peripheral blood T-lymphocyte subsets of the immunosuppressive mice. The results of this study provide a theoretical basis for clinical application, and a scientific basis for finding new effective immunoregulators of Chinese herbal medicine
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