Effects of chemical deactivation of the interstitial nucleus of Cajal on the vertical vestibulo-collic reflex induced by pitch rotation in alert cats

Abstract

The basic circuitry for the vestibulo-collic reflex (VCR) is a three-neuron arc, and this reflex requires the temporal and spatial transformation of vestibular signals to activate the appropriate neck muscles. Signals carried by vestibulo-collic neurons are insufficient to explain the responses of neck muscles. However, it is still unknown as to where the additional signal conversion is performed in the vertical VCR. We examined the effects of chemical deactivation of the interstitial nucleus of Cajal (INC) on the responses of biventer cervicis EMG induced by pitch rotation in the dark in alert head-fixed cats, and compared the results with the vertical vestibulo-ocular reflex (VOR) and also with the VCR and VOR induced by horizontal rotation. Muscimol infusion into the bilateral INC resulted in phase advance and gain drop in both the vertical VCR and the VOR, although the change was smaller in the VCR. The response phases of the horizontal VCR and VOR were not affected. Muscimol infusion outside the INC did not affect the phase of the vertical VCR or VOR. These results suggest that the INC is partially involved in temporal conversion of vestibular signals in the vertical VCR as well as in the VOR evoked by pitch rotation in alert cats.