Abstract
Plasma levels of immunoreactive atrial natriuretic peptide (IrANP) were measured in healthy normotensive subjects before and after saline infusion and changes in dietary salt intakes. When 2 litres of 0·9% saline (308 mmol Na+) were infused over 1 h, plasma levels (mean±SD) of IrANP increased from 5·8±2·8 pg/ml to 15·8+12·5 pg/ml. Plasma levels on the fifth day of a low sodium diet (10 mmol/day) were 3·8±2·4 pg/ml, a normal sodium intake (150 mmol/day) 6·4±2·9 pg/ml, and a high salt intake (350 mmol/day) 12·7±6 pg/ml. These results suggest that atrial natriuretic peptides could be important hormones in the control of sodium balance in normal man.
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